Targeted colonic delivery that works.
Challenges with Colonic Drug Delivery
•Limited fluid located in discrete pockets
•Variable intra-individual pH
•Little movement or agitation
•Varying transit times through GI tract
Current Methods to Deliver drugs to the Colon
Dissolution of pH dependent coatings e.g. Eudragit S
Degradation of coatings by colonic microbiota
Combined pH and microbial activated coatings
Timed release with
Tailored release of drug between 1 and 12 hours after dosing
Barrier layer erodes at a controlled rate prior to
drug release from the core tablet
Core tablet containing drug substance
OralogiK™ Erodible Barrier Layer enables high
drug loading in the absence of solvents
OralogiK tablet arrives in stomach where the
enteric coating prevents fluid contact with the tablet contents
Following gastric emptying, OralogiK tablet arrives in proximal SI and the enteric coat dissolves.
Time-based erosion commences.
Controlled erosion continues as the tablet transits down through the small intestine
Tablet arrival in the colon.
Core disintegrates and disperses in the colon.
Consistent performance, independent of GI tract variables
Erosion during GI transit ensures unimpeded release on reaching the colon
When combined with enteric coating eliminates variability of gastric emptying
Independent of pH and agitation
Clinical Evaluation 1
Enteric Coated Tablets with a 5 hour OralogiK™ Delay
Study Performed in Fasted Healthy Volunteers
10/10 dosages released in the colon, with 5 releasing in the AC, 4 in the TC and 1 in the DC.