Gamma Scintigraphic Imaging
Gamma scintigraphy is a versatile, non-invasive, imaging technique which offers early-stage evaluation of drug delivery systems in vivo, in real time.
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Why use gamma scintigraphy?
Scintigraphy is a powerful, fast and incredibly effective clinical tool which can improve early drug development productivity by assessing critical product performance parameters which in vitro methods cannot predict.
It provides direct quantification of pharmacodynamic effects and when paired with pharmacokinetic data offers invaluable insight into the mode of action of drug candidates. Scintigraphic data can also be used to support drug delivery claims, for marketing or regulatory purposes.
Applications in Drug Product Development
Assess prototype formulations
Lead candidate selection
In vitro / in vivo correlation
Dosage form erosion rates
Time and site of disintegration / dispersion
Applications in Pharmacology
Gastric residence / emptying – solid and liquid phase
Gastrointestinal transit times
BDD are market leaders in gamma scintigraphy with a proven track record and a global client base. For more than 20 years, BDD have helped our clients with exciting and challenging studies to understand better how their products perform in man. We have performed studies across a wide range of dosage forms including tablets, capsules, respiratory products, drinks, eye drops and nasal administrations.
Our studies open up a whole range of in-vivo data that is critical to product performance that cannot be obtained in vitro or through simulation studies. Data such as site and rate of release, gastric emptying, residence time and even rate of swallowing alongside pharmacokinetic profiles can offer unparalleled insight into your product behaviour.
Our expert staff have years of experience in analysing and interpreting scintigraphic imaging data to work with you to understand fully the data obtained from these studies.